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Given that GLP-1s carry a black box warning for thyroid tumors and additional warnings for pancreatitis and kidney problems, the lack of consistent baseline labs feels risky
At 80 weeks, all doses of retatrutide (4 mg, 9 mg, and 12 mg) met the primary and key secondary endpoints for obesity, delivering clinically meaningful weight loss
They would still not be FDA-approved medications, and clinical use should continue to be guided by the best available evidence, physician judgment, and informed patient consent
However, GIP immunoreactivity was identified in the adult rat brain using a specific monoclonal antibody against GIP (136), suggesting that while GIP is not expressed in the brain, peripheral GIP can reach the deep brain
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