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Mitochondria, the centres of cellular energy metabolism, exhibit unique biological characteristics during oocyte development.Compared with the typical branching morphology and structure of somatic mitochondria containing abundant crista, mitochondria in human oocytes and early embryos (up to the mulberry embryo stage) present a special round/cap-like morphology and poorly developed cristae, which leads to a significant reduction in their oxidative phosphorylation efficiency

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Cardiovascular outcomes data from TRIUMPH-Outcomes is long-term and would not gate the initial obesity approval, though it would shape any later cardiovascular indication