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It works through several mechanisms, such as suppressing appetite, increasing satiety, reducing food cravings and feelings of hunger, and delaying gastric emptying (the rate at which the stomach empties)

Semaglutide and tirzepatide studies show about 60% of lost weight returning within a year, with most regain in the first months and about one-third to 40% of the loss still held at one year. Retatrutide may produce greater regain pressure because its glucagon support for resting metabolism fades while appetite returns