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View Study [3]"IGF-I and IGFBP-3 transport in the rat heart" Boes M, Dake BL, et al., 2003 Finding: This study showed that LR3 IGF-I can bypass IGF binding proteins that normally sequester IGF-1, demonstrating why LR3 has greater bioactivityit reaches target tissues more effectively than native IGF-1

We will work closely with the FDA to determine the necessary next steps to complete the review process, aiming to offer this innovative treatment option to adults with diabetes. Novo Nordisk submitted the insulin icodec application to the FDA in April 2023

Selected Research Highlights GH/IGF-1 Axis: Used to probe pituitary output patterns and downstream signaling cascades associated with GH biology

Considered a specialized peptide within neuro-focused research categories