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It binds to drug metabolites, alcohol byproducts (acetaldehyde), heavy metals, environmental pollutants, and other toxins through a process called glutathione conjugation
By incorporating peptide sequences into the linker, cleavage occurs only in tumor cells or endosomal/lysosomal compartments with specific enzyme activity, enabling selective payload release, improving drug targeting, and reducing toxicity to healthy tissues
After careful screening, the literature closely related to the topic was finally selected for evidence integration and mechanism exploration
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